I use it on macOS and Windows, and it is lovely! I even have Steamworks.NET integrations working on both platforms with it. It can be a bit tricky to setup the `.csproj` correctly to resolve native dependencies, but not anything impossible.
If you don't mind me tooting my own horn too much, I have some docs about project setup in the readme for a test framework I made for C# Godot games. It has some notes about mac-specific things, since that's my primary machine. https://github.com/chickensoft-games/go_dot_test
You can also look at the way that project itself is setup, and the `.csproj` files. If you need more help, feel free to join our Discord (link in the blog)!