[danachow]

> Most of these are products of high uric acid level

That's a very unsubstantiated claim. I'm not debating the association of hyperuricemia with metabolic syndrome or cardiovascular risk factors, but I don't think we have much evidence to establish a causal link between hyperuricemia and all the morbidities listed.

[ncmncm]

Robert Lustig:

https://m.youtube.com/watch?v=kDJsxw0uMLM

Perlmutter:

https://m.youtube.com/watch?v=6qZKH_xuYl4

[danachow]

This is not an RCT nor does it point to one supporting your uric acid claims.

And Lustig is well known, he's on the border of being a crackpot, unfortunately. Mehmet Oz is a professor emeritus of Columbia, and contributed some amazing shit to the field of cardiology, but now he is undoubtedly a crackpot, so just having some credentials and even a good history is not an automatic pass to get out of presenting high-quality scientific methods.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822166/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078442/

And.. this is not the first time this has come up here even: https://news.ycombinator.com/item?id=15760599

[ncmncm]

You will have to take up your objections with the endocrinologists. Good luck, though, 'cause endocrinologists are the smartest of all medical doctors. Have to be, to do it at all.

[danachow]

This is a non-response - or do you have a specific cite linking uric acid as causative of diabetes or cardiovascular disease? It can be in a colorectal journal for all I care.

> Have to be, to do it at all.

Lol. Yeah bud, I have a ton of friends that are endocrinologists, all mostly great and intelligent folks, but I’m not letting them touch me with a colonoscope - or pretty much any implement. It’s not exactly a field for the procedurally inclined.

[ncmncm]

So, ask them. It is their job to know. You have already said you don't trust me.

Be sure to report back what they tell you.

[willbw]

Ignoring who is wrong or right here - you made the claim, it's not very helpful if you refuse to substantiate it or suggest someone else needs to substantiate it for you.

[ncmncm]

Notably, this person has not reported any results.

Most likely they don't actually know any endocrinologists, or were told that in fact uric acid is known to be the connection between fructose metabolism / fatty liver and metabolic syndrome illnesses.

Some people just feel compelled to jump up and defend sugar anytime it is blamed for illness.

[danachow]

> this person has not reported any results.

Ironic since you are the one making the claim and have not produced any references. I can’t prove they don’t exist but you could easily counter if one did.

Furthermore I linked to one peer reviewed review article, again https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078442/

that is chock full of balanced references if anyone is so inclined to peruse them and takes a critical examination at the various publications and the arguments can be evaluated solely on merits alone. There is continued research in this area but so far no smoking gun as to causality.

There are no meta-analyses I know of on your specific claim as there is a lack of primary research in human subjects to even substantiate it.

> Most likely they don't actually know any endocrinologists

I’m a practicing academic internist. I know endocrinologists both personally and professionally. This is absolutely irrelevant though as the literature is available for you.

> Some people just feel compelled to jump up and defend sugar

I did nothing of the sort. I treat diabetes and hyperlipidemia on the daily - that would be ridiculous.

Edit: oh and I missed your edit - a reference to Perlmutter? A celebrity neurologist who has widely been debunked for making wildly unsubstantiated claims. You are not arguing in good faith. You have the entirety of PubMed and Google scholar on which to reference peer reviewed literature - some of it is also crap - but you aren’t even doing that - you are sticking to the lowest quality unsubstantiated celebrity bilge.