They won't auto-generate thousands of replica KFC restaurants in rural Mongolia, as they did in Flight Sim 2004. If Google Image Search worked anymore, I'd link a screenshot.
'Culture' in the sense of human artefacts (buildings, etc) laid down on an underlying terrain. Such culture will be specific to particular regions of the world.
I would think things like roofs. If you're flying over Florida, make it "culturally appropriate" by making the roofs look like they are made of that tile rather than regular shingles.
Edit: There's a Florida joke in there somewhere but I'm not going there.
https://www.flightsim.com/vbfs/showthread.php?48720-Giant-ch...