No, they aren't hard to use. They may be different to package than for, say, Linux, but even that is just different and not harder. (And it's not even different significantly if you use pyInstaller.)
As a user of various python apps on windows I can tell that in practice it’s one of most confusing experience among all other languages. I have to purge everything python-related and reinstall it once a year.
If you are using apps that have been packaged with PyInstaller (or a number of other methods) for end-user use, I don't understand this: I use a number, and it's completely painless.
If you are using a systemwide Python installation and installing apps into it with pip, then, yes, that's potentially a world of needless pain.