[nothinggoesaway]

Great context, discussion: https://www.genengnews.com/topics/drug-discovery/therapeutic...

> Higher intensities of the same sounds had no effect on animals’ pain responses. “In mice, we found that sound-induced analgesia depended on its low SNR rather than harmony, which is supported by a previous hypothesis that music-induced analgesia is attributable to contextual factors of the treatment, not only to the music per se,” they wrote. “We were really surprised that the intensity of sound, and not the category or perceived pleasantness of sound would matter,” Liu said.

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> The authors further stated that the observed low-SNR sound–induced analgesia is “unlikely to result from some reduction in anxiety or stress, and it probably does not directly involve attention-distraction in affecting pain perception, given that the analgesic effects persisted for at least two days after sound withdrawal.”