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by acdha 1458 days ago
> Flu vaccines are not designed to stop Alzheimer's. There is no argued or known biological pathway through which that might happen.

You might want to read the paper before saying untrue things like that so confidently:

“Mounting evidence indicates that systemic immune responses can have lasting effects on the brain and can influence AD risk and/or progression. A diverse range of microorganisms and infectious diseases have been associated with an increased risk and/or rate of cognitive decline, particularly among older adults, including influenzal respiratory infections [5, 6], pneumonia [4, 7], herpes infections [7], chronic periodontitis [8], urinary tract infections [4], gastrointestinal infections [9], sepsis [4], and most recently COVID-19 [10]. Prevention or attenuation of microbe-related inflammation may therefore represent a rational strategy to delay or reduce the risk of neurodegenerative disease. Consistent with this hypothesis, studies have found a decreased risk of dementia associated with prior exposure to various adulthood vaccinations, including those for tetanus, diphtheria, pertussis (Tdap) [11–13]; poliomyelitis [11]; tuberculosis [14, 15]; herpes zoster (i.e., shingles) [6, 13, 16, 17]; and influenza [11, 18–21].”

Unlike your Nick Cage theory, this has a clear mechanism and is compatible with the understanding of similar effects.

1 comments

That supports my point, no? The paragraph you cited boils down to "there is an association between being less sick and not getting Alzheimer's (i.e. being less sick" + "there seems to be an association between literally any vaccine regardless of mechanism or target and less Alzheimers". These are not specific biological mechanisms of action, they're just correlations supported by an ultra-vague causal hypothesis of the form "maybe microbes cause Alzheimers". That's not actually a causal biological explanation.