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by kaitaincps 1461 days ago
There of no known lineage B sarbecoviruses that have a furin cleavage site, at least not prior to SARS-COV-2. This polybasic furin cleavage site is found in various proteins from many viruses, including Betacoronavirus Embecoviruses, and the Merbecovirus. However, within the betacoronaviruses of the sarbecovirus lineage B, this type of site is unique to SARS-CoV-2. It's never been seen before.