[civilitty]

The GP is talking about the "overall chemical profile" that depend on the strain and growing conditions. There are over a hundred cannabinoids identified in cannabis that have a variety of effects in humans (not to mention the terpenes/terpenoids), including several that are produced when THC oxidizes so the "overall chemical profile" depends on the age of the plant matter in question as well as how it was processed and stored.

Whether the Indica/Sativa marketing labels correlate with that chemical profile or not is besides the point. We know that different batches of the same strain can have different concentrations and ratios of all the of the relevant compounds because most legalized states require testing every batch. I don't know of any high quality research that studies how the subjective experience correlates with different doses and ratios but given that at least one of the most common compounds in cannabis is FDA approved to treat epilepsy (Epidiolex) and all the anecdotal evidence, it's really not a stretch to see how different strains produce different highs in different people.