[autoexec]

This makes me wonder about the people who seem immune to the effects of cannabis. If the problem is their receptors would that impair their ability to take advantage of Anandamide and the body's other cannabinoids as well and if so, what are the impacts?

[aaaaaaaaaaab]

No.

Their mutated receptors can reject THC while still accepting their own endocannabinoids.

[0des]

Every time I have encountered one of these people, they try a single dab and suddenly it's myth-busted.

[autoexec]

It seems pretty common for people to not have or notice any effects the first few times they try it, so some people may think they're one of the immune until they aren't, but I've met a few who do seem unaffected after many attempts. Some say they don't get that natural "runners high" either. It's all just subjective and anecdotal though. I haven't personally seen research on the subject yet.

[ksaj]

This is correct. I've heard about this a fair amount afterward, but when I first tried it in grade 7, I got absolutely nothing from it the first time. I smoked tobacco then, so I was plenty experienced with inhaling etc.

The lack of effect made me feel a bit cocky, so the next time I went in all bravado. I got super stoned and could barely stand or walk while I was adjusting to it. I was quite impressed and humbled immediately.

Nowadays I get runners high running for my stash. Kidding. The rest is true though.

[scotty79]

I think THC lingers in your body for weeks and makes your body more susceptible to THC. So the first time often does nothing. But getting another dose for example two weeks later will result in noticeable effects.

[hallway_monitor]

I've gotten plenty high but never this elusive runners high people talk about. I guess it must be why some people like to run more than half a mile and I'm missing out!

[ksaj]

I've only experienced Runner's High one time that I am aware of.

I was never a good runner. But in grade 7 and 8 we used to run a regular route for gym class. I always had to walk parts of it. But in grade 8, we had "The Great Race" and for whatever reason, I guess since it wasn't just my usual gym classmates, I got all competitive and managed to run the whole thing. I still lagged way too far to win, but I made it without stopping.

There was a point, a ways after the first point I would normally give up and walk a bit, that I suddenly felt "This is easy" and everything just flowed. So I just kept going and finished the race.

When it was over, it was a chore trying not to vomit.

That was a definite breakthrough stamina moment.