[sungam]

A concern with using cyclosporine for neurodegeneration may be that it causes progressive kidney damage and high blood pressure with long term usage. We use it a lot for many immunologically mediated skin diseases however almost always plan to change after a year to an alternative for this reason.

Regarding chronic idiopathic urticaria - cyclosporine was used in the past but now in the UK omalizumab is licensed for this and generally is more safe and effective.