[myst1]

Most of the reproducibility issues in chemistry happen in biochem in my experience(meanwhile it gets the most funding). That said, synthetic chemistry is also a problem area. Usually in synthetic chemistry it's not that the work can't be entirely reproduced, but rather that yields are fudged. That's mostly because PIs say "you can't graduate until this reaction yields 99%.". So after someone has written four papers, taught classes at minimum wage for 7 years, they fudge a 95% to a 99%. It's not okay, but neither is the way academia is structured. Super glad my discipline was elsewhere, but I saw colleagues suffer from this stuff...