[JudgePenitent]

"In short, machine learning methods are in place, but accessible data is not."

"Finally, one must address the concerns of various commercial stakeholders."

"A few chemical databases of reactions do exist, but these are commercial (e.g., Beilstein/Reaxys [Elsevier], SPRESI [InfoChem], and CAS [ACS]), and even when a license is purchased, the underlying data are accessible only through a narrow, one-query-at-a-time interface, completely stifling the application of powerful artificial intelligence and machine [...]"

This seems like the first point of approach, not the last. Can anyone comment why these data gatekeepers have not made a business model to give programmatic access to nerds?

And if they have financial reasons for not doing so, how will governments sweet talk shareholders into supposedly losing money?

[myst1]

Ignoring machine learning entirely... Chemists benefit from this. Being able to type in a moiety and the product you want saves a bunch of trouble...