[jreese]

FWIW, that version ends up being slower, because you're constructing and iterating over a tuple for every iteration, which incurs a similar cost to running `.strip()` twice. The sub-generator example I gave is better because you're only constructing the generator expression once, and requires less overhead for each iteration.

[d0mine]

It is unlikely (unless there is a benchmark that says otherwise). Before the walrus operator, the single item loop could have been used:

  nonblank = [value for line in file for value in [line.strip()] if value]