[genedan]

Have you Transport Fever 2? The AI manages growth of the cities while you work on building out the logistics. The better your network, the faster the cities grow. Since there are planes involved I would classify the scale as being nation-sized.

[pornel]

Yes, but the scale of things in TF2 is very symbolic. Cities are a couple of train lengths long at best, and grow by attaching new short roads at random. That's fine for the needs of the game, but isn't really a country-sized simulation.

[fendy3002]

Similar with it's predecessor, transport tycoon or the newer openttd

[mhio]

There's also Voxel Tycoon in the same vein. Early access but polished enough to have a go. It adds a dash of Factorio to the resources.