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by kpfleger 1488 days ago
One reason getting these from the evolved route may be better is because feedback mechanisms stop making the beneficial substance when the body has enough, which may not happen via intake by other methods. This is the case for vitamin D from sun vs oral D supplements. Serum levels stop going up when they reach a natural adequate evolutionary range if it's coming from sun. I don't know if that's true of NO or not. Or of melatonin from the near-infra-red wavelengths, but I wouldn't be surprised.
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> This is the case for vitamin D from sun vs oral D supplements.

Wait, has there been a study suggesting this? This implies that there's a narrow optimal range and exceeding it causes problems. Seems you would see this in the supplement trials. Vitamin D toxicity doesn't occur until you take many times the RDA for months, and presumably none of the supplementation trials went anywhere near that high. https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-h...