[simonh]

Does anyone know if the Framework laptop use a mainboard form factor that is available with AMD chips?

The modularity of some components can be assumed because they are industry standards, like wifi modules I suppose. Other components perhaps Framework have designed their own range of modules with a common form factor, but it must be very expensive to engineer a compatible mainboard in the same form factor with a different chipset, unless they are using an existing standardised design.

[Sebb767]

I'm not totally sure, but I think their mainboard is of their own design. They would need to adapt, but they could do it. I also think the differences are not too large, since most mainboard manufacturers offer surprisingly similar mainboards for either brand.