What features exactly are you looking for? I have only used emscripten but you can compile debug builds and step through the code in the browser's inspector.
I don't know enough about wasm runtimes, but for example JIT runtimes like nodejs (or JVM via perf-map-agent [0]) allow writing out debug infos via the Linux Kernel JIT-Interface [1], which debuggers and profilers can then pick up to symbolize stack traces. Not saying that it has to be the Linux JIT perf-map interface, but it'd be nice if it's something implementors of the runtimes kept in mind (not implying that they're not, I just haven't read anything).
[0] https://github.com/jvm-profiling-tools/perf-map-agent
[1] https://github.com/torvalds/linux/blob/master/tools/perf/Doc...