[segmondy]

It's still possible to do so. Just get an EE degree, you will understand hardware down to the gate level. Take a solid CS course and you will understand software down the basic levels. Understanding hardware to OS is something that a lot of people still know, what is difficult to know these days is the layers of software by 3rd parties running on the OS.

[izzydata]

You can analyze any single part of a modern large piece of software, but I think the point is that you can no longer remember the entirety of the software or hardware. Even a single function is going to get compiled through multiple layers of obfuscation until it hits the hardware and at that point modern CPUs are also extremely convoluted. Nobody is going to know how a function on your OS will compute with absolute certainty.

[kevin_thibedeau]

Not all modern CPUs are high performance devices. In fact the vast majority of microprocessors are no more complicated than an early minicomputer.