[pure_simplicity]

There is not much to question about TMAO being bad. Fish having a high Omega 3 content which is protective against atherosclerosis may explain why TMAO from fish consumption is not as problematic as that from consumption of other meats. Before we start reconsidering if TMAO is bad, it's far less speculative to consider whether tmao's bad effects that are known have been offset by positive effects of omega 3 which are also known.

[Terry_Roll]

I wonder whether atherosclerosis is increased with lower vitamin K1 intakes, you see the arteries get harder with low K1, too much calcium and phosphate rigidise the outer wall, to the point they become hard like metal tubes. Now with plumbing and scale from hardwater, scale forms more easily on hard inflexible surfaces than flexible surfaces. So K1 puts the elasticity back in various tissues which makes me wonder if the plaques are then capable of forming and importantly adhering to the surface? There is also a case for regular exercise to increase the blood pressure operating range, ie going from low to high blood pressure and back again.

So I'm not totally convinced at this stage that TMAO is actually bad for us, it just seems to stimulate so parts of the immune system.

Besides there are ways to reduce TMAO, like consuming more Taurine (Red Bull), using nicotinic acid which incidentally also increases the release of triglycerides from adipose tissue, I got a six pack just from 500mg of nicotinic acid a day and walking, the only non patentable statin that is and arguably safer considering the man made statins can cause brain fog amongst other side effects.

Carnitine and nicotinic acid would certainly go well together for weight loss, but it definitely needs some K1 then to protect the tissues & K2-mk4 to protect the bones if doing nicotinic acid.