[gpvos]

There used to be some good intercity trains from Brussels via Luxemburg to Strasbourg (Iris and Vauban), but they were cancelled in 2016 because of the TGV Est Paris-Strasbourg. It's a bit long for a bus ride really, especially when you'd want to work during the ride.

Edit: oops, this is about Frankfurt-Strasbourg. (Sorry, I mixed it up with some other fairly recent reporting.) That's really hard to justify: there are high-speed trains doing that route in 1h50, and a non-stop one could do it even faster.