[rhema]

My mother-in-law has severe eye problems and MS type symptoms. 16 years ago, I showed her how ctrl shift +/- could make her fonts huge. This one tip that is not obvious to most folks improved and continue to improve her quality of life _drastically_.

[mc4ndr3]

Increase at OS level, instead of having to repeat this step manually for every app and website.

[account42]

These days, setting a higher DPI system-wide is the best solution. In 2006 it probably was not.