[thelazydogsback]

Note that this study shows that supplements increase _blood serum_ levels of NAD, not concentrations inside the cell and mitochondria where it counts. So I'd say that without further qualification, this study shows safety more than efficacy. The role (if any) of exogenous NAD precursor supplementation is still a topic of debate, and there's a lot of money in selling these formulations. FWIW, I personally take NAD precursors because they likely do no damage (other than to the wallet), and they possibly do some small amount of good. There are plenty of other supplements I'd spend my money before NAD precursors. (And of course diet and exercise outweigh them all for most...)

[xiphias2]

250 mg/day is 4.4 mg/kg. In the mouse study published in Cell they used 400 mg/kg/day.

I believe safety at these levels is irrevelant, so I prefer just working out every day and limiting my sugar and alcohol intake, all of which have proven life extension effects.

[xvector]

NAD precursors can vastly accelerate the development of any pre-existing cancer you might have, but not know about: https://www.reddit.com/r/NicotinamideRiboside/comments/mvr6x...

[SubiculumCode]

Is it generally available to buy?

[faluzure]

Yes, but you've got to be careful as there's plenty of fake NMN out there, and it's also not shelf stable according to David Sinclair (in a tweet).

The stuff I got was from Alive By Science, now Renue, and they claim theirs is shelf stable. https://renuebyscience.com/how-long-does-our-nmn-retain-its-...

[Eduard]

I get NMN from https://youngle.com/ . Their NMN purity is verified by a German laboratory: https://youngle.com/

[thelazydogsback]

Sure - you can find many NR and NMN supplements on AMZN for example. NMN has gained popularity over NR, I believe mostly due to longer shelf life. Elysium and TruNiagen are two famous brands, that IIR were sueing each other at some point? I take another/cheaper NMN supplement. Caveat emptor - there's really no way to tell what you're getting from many of these - and even if you're getting pure ingredients, the jury is still out.

[criddell]

For the past couple of years I’ve been taking Nicotinamide Riboside I buy on Amazon and it has basically eliminated inflammation and pain I used to get in my hands, wrists, and sometimes elbows. FWIW, I’m going to be 52 this year.

[WraithM]

You can get NMN at most supplement places. NootropicsDepot sells it for example.

[banq]

proHealth NMN is good: https://www.reddit.com/r/NMN/comments/rsbne9/fake_nmn_produc...

[h-w]

What are your “before nad” supplements?