[elithrar]

> At 11 stops up from ISO 100, you're getting to have a great deal of noise at the max ISO I would have thought even at full frame.

You'd be surprised how clean some of these things are, especially so if you don't plan on blowing things up big. Plus, with NR software these days, you can easily get usable 12,800 ISO & 25,600 ISO shots if you expose them well.

The real trick to shooting in low-light is nailing the exposure; too dark and you'll have dirty highlights, too light and you'll have blotchy, noisy shadows.

[apgwoz]

I'm still using a D70s as my primary camera, but I have to say, when Nikon released it's first camera that supported ISO 6400, they made available full resolution JPGs. You could see a bit of noise if you looked really hard for it, but, it effectively wasn't there. I can only imagine that 25,600 ISO is almost just as good as that. And, quite frankly, it's simply amazing.

[dconway]

Sweet. I've always wanted to look inside people's pores.