[biguanide]

Perhaps the most promising anti-aging drug is metformin.

Type 2 diabetics on metformin live 15% longer than non-diabetics. This is remarkable, considering how big a health disadvantage diabetes itself is.

Metformin seems to mimic fasting somehow, by interfering with mitochondrial function.

For more information, I refer you to David Sinclair's numerous discussions on this topic. He takes 1 gram of metformin per day, with his evening meal.

This is not medical advice.

[gorkempacaci]

Recently I’d seen this on Metformin: https://www.science.org/content/article/rare-genital-defects...

[hirundo]

> by interfering with mitochondrial function

Which mitigates the damage caused by the toxic components in his evening meal. If the meal is unalterable that's a good move. But most people can do a lot more good by removing the ingredients from the meal that stress the mitochondria, particularly the excess carbohydrates and polyunsaturated fats. That same deadly duo is also responsible for atherosclerosis.

[robbedpeter]

Your assertion depends on his evening meal being deleterious.

https://naturallystrong.me/david-sinclair/

He's got an excellent diet. He's also got very solid reasoning behind metformin supplementation, having done years of research and investigation. He's a smart and respectable guy, operating in good faith with his research, so if you find yourself disagreeing with him over something trivial, it's unlikely you're right and he's wrong.

Implying that metformin is useful only to mitigate hypothetical harms from nutrition (a trivial dispute) is probably wrong.

Across various interviews, he's recommended metformin for exactly the mitochondrial effects you're talking about. He doesn't supplement on workout days to prevent disruption of the healing and recovery. Metformin isn't something that anyone should start taking blindly or blithely, as it can amplify damage from other circumstances, but it's got a clear place in Sinclair's regimen for very good reasons.

Metformin's longevity effects work on a lot of species. It's got solid science recommending it for life extension, like the other things Sinclair uses, but unless you're a doctor, or work with one to create a comprehensive life extension, health, nutrition, and fitness plan, metformin probably isn't a great idea. Sinclair is doing something similar to juggling chainsaws - it's really cool that he can do that, but it's dangerous for amateurs. Too many unknowable factors can blow up in your face.

Then again, maybe it'll be part of a standard regimen in the next decade, and the immortals are living among us.

[SemanticStrengh]

It's not.. I could have shown you the most potent geroprotectors but tragically the website is down... https://geroprotectors.org/

You should look into SkQ1 + NAC instead.