I'm using a pretty underpowered PC 1000 series graphics card. It chugs. Building for the Quest 2 using UE5, Blender, and a few plugins and templates from the unreal ecosystem.
I also have a huion drawing tablet but I think you could go quite far in blender with just a mouse.
I also have a huion drawing tablet but I think you could go quite far in blender with just a mouse.