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by Knufen
1519 days ago
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As other posters note some feed-forward defense mechanism requires a larger dose to elicit a response. Sometimes small doses have a cascade effect meaning A->2xB->6xC etc whereas a larger dose would activate a feed-backward mechanism between B and C. A classic example is endocrine disruptors (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036398/), a small dose induces a hormonal response, a medium dose the body fights due to detecting it as foreign and a high dose is just regular toxic. Please note this is somewhat simplified but used as an example. |
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