[GuB-42]

This effect has always puzzled me, so much that initially thought it was pseudoscience (like homeopathy). I mean, in a real U curve, the highest effect is at a zero dose and it makes no sense.

But it looks serious, peer reviewed papers and all that. The main reason seems to be that at a low dose, the chemical doesn't trigger "defense" reactions and can do its thing unimpeded (high effect), on a medium dose, our body starts to notice and dampen the effect (low effect). High doses are simply overwhelming and the effect becomes high again.

I still think there is a lot of pseudoscience around that effect that helps selling a lot of "natural", "detox", etc..., but I don't think all of it is bullshit anymore.