[Sohcahtoa82]

> Aside from significant whitespace (which I suppose takes a little getting used to),

If Python's whitespace takes getting used to, then you're probably poorly formatting your code to begin with.

[jgwil2]

One thing I do find mildly annoying about the whitespace is that you can't jump to the end of a block with e.g. % in Vi (goes to the matching bracket). Not a huge deal but something I notice.