[vharuck]

REACT

PIOUS

Hits all the vowels except Y. But I feel like it's not so great. Wish I could replace the P with something more useful.

[mod]

My friend opens with ADIEU

I think it's bad strategy, but might help meet your goals, because D is pretty good.

[Ishmaeli]

ADIEU

STROY

All the vowels and the three most common consonants in two words.

[pxeger1]

Do you mean STORY, not STROY?

[Ishmaeli]

That's funny, STORY is much less esoteric, isn't it?

[adrianmonk]

CLEAR

PIOUS

I also want to hit all vowels ASAP, and I'm also dissatisfied with that P.

[CameronNemo]

I do RAISE and COULD often.

[dgfitz]

Spoiler, stop reading if you started playing worldle in the past 3 months.

I used could a lot until it became one of my o my 2-guess wins. Now I hate using it knowing there is zero chance it’s the answer. I still do occasionally if someone after 3 guesses all 5 of those letters are available, which is almost never.