[michaelrpeskin]

There are two subtleties about this that often are not talked about.

1) The caloric restriction -> longevity research shows that it's generally true, but it much more pronounced in small creatures that spend a significant amount of "lifetime energy expenditure" during reproduction (like mice). So while caloric restriction makes a mouse live 30% longer (making up numbers here), the same proportion of caloric restriction may give <1% extra life in a human.

2) There often a quantity vs quality of life trade off too. Let's say reducing mTOR and BCAA takes a few years off of your life but you have much more muscle and with that great posture and movement that doesn't break down your body and you feel great (and if we believe the linked article more sex too). Is that a trade off you're willing to take?

Same argument can be made with HRT for older men (I'm nearing that age). It seems that lots of the scary news related to HRT and anabolics in general is more about looking at the negative effects without accounting for the quality of life improvements that come from just being stronger.