If backend services are written in TS (instead of JS) then you'll need to compile to run it. Be that TSC or webpack with ts-loader, you'll need something to perform that step. I don't think anyone is running ts-node outside of local dev environments.
I'm just now finding that webpack is mostly a foreign concept in backend nodejs tech, but it's mind boggling to me that the norm was to ship code with the node_modules folder instead of bundling and minifying. Seriously, why? It's so wasteful... :'(