[Someone]

> a resource humanity has depleted and not effectively replaced or otherwise made irrelevant?

If we were to have depleted something we need without finding a replacement, humans would be extinct by now, or at least on a path towards it.

We’re alive and, on average, extremely safe (life expectancy is higher than ever, despite obesity, opioids, etc)

So, if we assume that we’re better of than ever in history, I don’t think there can be any way the answer to that could be “yes”.

Of course, one can claim that assumption doesn’t hold. for some, having all the modern stuff may not make up for not being able to see dodos, passenger pigeons or huge herds of bison.

Even a resolute “no” answer doesn’t say much, though. Past performance is no guarantee for future results.