[ThinBold]

After ten years of "we are getting to the last mile" and "we are finally completing", it just feels like bio people cannot give up this good reason when justifying their funding so we have to re-complete human genome every other year.

[robwwilliams]

Not so. This work is real progress brought about by significant technical innovations over the last 5 years. I name three:

1. Two cool long-read sequencing technologies (PacbBio HiFi and Oxford Nanopore)

2. Hydatiform moles carrying human chromosomes for easier sequencing

3. Excellent code for assembly through complex regions of the human genome (e.g., code for assembling pangenomes by Garrison and Li).