[sva_]

She later did so much MDMA, that it now doesn't have any effect on her anymore, she claims. Doubt she tried it recently though, as she's 91 now.

Incidentally, Shulgin didn't discover MDMA himself. It was discovered around 1910 IIRC, but hadn't found to be useful back then. He rediscovered it much later.

[agency]

I've heard similar accounts of MDMA losing effectiveness with folks who have used regularly for extended periods of time. I haven't experienced it myself but I try to wait at least 8-12 weeks between uses. I have a theory that for many people it comes down to the highly variable quality of what you get on the street. I buy all my stuff on the dark net and test it, and after figuring out a couple of other variables that have a big effect on me (mainly: timing of food consumption. I fast minimum 5 hours before a roll) I have had very consistent experiences. But the quality issue would certainly not be at play with the Shulgins so I wonder if there's something to the long term effectiveness stories.