| You want to see funny? You said: > One of the main theories on the action of MDMA involves the sudden serotonin release inhibiting the amygdala and thus reducing fear response. Prozac certainly does not do this. {cough} Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832021/ Chronic fluoxetine prevents fear memory generalization and enhances subsequent extinction by remodeling hippocampal dendritic spines and slowing down systems consolidation https://www.nature.com/articles/s41398-019-0371-3 Serotonin-2C receptors in the basolateral nucleus of the amygdala mediate the anxiogenic effect of acute imipramine and fluoxetine administration https://academic.oup.com/ijnp/article/15/3/389/720875?login=... You read some articles. That is not enough. You are being duped by more pharmaceutical company propaganda. Have you ever ask yourself why they don’t investigate the reason people are not producing enough serotonin? Or white people lack serotonin? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337390/ |
Also, from your first link: "In contrast to fluoxetine, citalopram treatment did not increase BLA eCBs or facilitate extinction." And your second link: "Importantly, other SSRIs such as citalopram have shown the opposite effect, disrupting acquisition and retention of fear extinction"
Yeah...
Plus "fear extinction" is not the same as immediate fear reduction/inhibition as seen with MDMA.
I think that we as humans like to believe that we know more than what we do about these sorts of things.
Edit: Your third link talks about anxiogenic effects of fluoxetine, i.e. increases anxiety; literally the opposite of what you are arguing.