[pmags]

1) I'm afraid you're about 15 years out of date with your perception of how genome sequencing and assembly works. Nobody is assembling PacBio, MinION or other long-read data (or short read illumina data for that matter) with slow aligners in Perl.

2) see AlphaFold2 and other related methods -- the protein folding problem is still a big challenge but the field is moving in leaps and bounds

[simne]

1. You should read carefully and not tie to some part of text and miss all others.

2. Author asks about biggest opportunities, and I give example. I suggest you to learn, how to be less toxic in conversation, as this will make your life better.