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by jamesash
1546 days ago
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Interestingly, cyclobutane and cyclopropane do not have a large difference in ring strain (within about 4% of each other).
Cyclopropanes are well known in natural product structures.
One of the weirdest is this natural product, U-106305, which has 6 cyclopropanes. Made by a strain of Streptomyces!
https://pubs.acs.org/doi/pdf/10.1021/ja9619420 |
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