It's likely too big for those programs - I am (just now) starting a build with the Open Lane/Sky tools not with the intent of actually taping out but more to squeeze the architectural timing (above the slow FPGA I've been using for bringing up Linux) so I can find the places where I'm being stupidly unreasonable about timing (working on my own I can't afford a Synopsys license)
I'm just starting this week, I've recently switched to some use of SV interfaces and it does not like arrays of them - sv2v seems the way to go - but even without that yosys goes bang! somethings too big Vivado compiles the same stuff - I rearchitected the bit that might obviously be doing this but no luck so far.