Just within Mac they've gone from 680x0 to PowerPC (related to POWER but separate), to AMD64, to Apple Silicon. Before the Mac, they also had the 6502 and 6800 platforms.
They went 32 bit x86 before adding support for amd64 bit and then eliminating 32 bit right before going to apple silicon (presumably in part motivated by rosetta 2 being optimized for translating amd64 software)