[derbOac]

I guess I had a few reactions offhand:

1. Pretty interesting.

2. The criteria for reproducibility seem a little rough to me? They seem to be sort of distant from things like registered replication, publication bias analysis etc.

3. My gut impression is you need some kind of meta-scientific model, eg something that models the probability of studying an association, the observed association conditional on that, effects on heterogeneity of effect sizes etc.

4. Along those lines, I wonder if there's an implicit schema of looking for nonzero associations and documenting them rather than reporting best estimated strength of known association? Maybe not.

5. I'm curious how you define nodes/topics versus subnodes/subtopics. I suspect defining the nodes/topics and their boundaries would become tricky?