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by astrange 1567 days ago
It's BDNF. Lion's mane is just a supplement which promotes that, but there's other more effective ones. And of course the artificial ones are stronger (Noopept, Semax, ketamine).
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>Ketamine, an N-methyl-D-aspartate receptor antagonist and putative antidepressant, may increase synaptic plasticity in prefrontal cortex through higher expression of BDNF. Furthermore, ketamine was shown to change resting-state functional connectivity (RSFC) of dorsomedial prefrontal cortex (dmPFC).

That is really fascinating! I wonder whether the lesions observed in chronic, heavy ketamine abuse are related to trophic effects.

A glance at search results sugget BNDF seems tighlty regulated, and linked to lesions in other rare conditions

(This makes me want to buy neuroscience books! Such an interesting field)