The only use I saw for this is that you can enable compiler flags to crash the program when NaNs are encountered. Useful for testing Fortran code, in my experience. I didn’t see any support for other languages I’ve used.
C lets you set and query the flag state with the `<fenv.h>` functions in theory, but compiler support for rigorously adhering to IEEE 754 semantics around these operations is pretty limited in most compilers, to say the least. Clang has been making some progress on support recently.