[cottager2]

Do you have a source for the claim that most studies done in mice don’t hold up? As far as I know, mice are quite a good proxy, although there are some differences. It seems like it would be a complete waste of time to study mice if most results didn’t hold.

[Avshalom]

You can start with following footnotes from https://en.wikipedia.org/wiki/Laboratory_mouse#Limitations or https://en.wikipedia.org/wiki/Animal_testing#Scientific_crit... I guess; I doubt it's possible to show what % of mouse studies hold up or don't hold up.

[zdragnar]

The post itself includes a caution against applying this information directly to humans. It is a sign further research is warranted, nothing more (as opposed to completely pointless).

[09bjb]

Mice strike the best balance for science of animals who are decent proxies for humans, are inexpensive to breed and genetically manipulate, and who don't trigger much ethical backlash.

It seems to me though that the extent to which mouse biology and behavior translates well to human biology and behavior might also be the extent to which it's totally immoral. "Yes, but think of how many future lives I'll save by vivisecting this sentient or semi-sentient being..."