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by s1artibartfast 1588 days ago
You are right that the study simply isn't powered to detect a decrease in mortality, even if it is there! That said, if true, a 70% reduction in mortality would still be of significant benefit.

You are right that this study doesn't change the picture. It is is just another underpowered study showing a large but statistically insignificant reduction in mortality. Yes, Paxlovid is almost certainly better.

That said, I would like to understand the efficacy of ivermectin with an appropriately powered and designed study. I hope ACTIV-6 reports out this year and used a reasonable treatment dose and timing comparable to Paxlovid.