I raced my hand built wheels on tour divide. They didn't explode, unlike a lot of people with overpriced wheels from "specialists". Granted, tour divide is the extreme end of endurance though.
I've seen more than one overtensioned bikewheel completely lose it, especially wheels with reduced numbers of spokes should be tensioned 'just so', too tight and you're waiting for a wheel failure, which if it is your front wheel at speed could very well land you in the hospital or even kill you.