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by johnisgood
1587 days ago
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Are people who take antidepressants addicted? The reason I am asking is that opiates can be used as such. > Opiates promote goal-directed behavior. > Interestingly, the mechanism of antidepressant action for ketamine may not even involve NMDAR blockage and may instead involve modulation of other CNS binding sites, such as being an agonist (activator) of opioid receptors. I can see how opiates would help with anxiety and depression, especially for people who do not experience euphoria from it, just enough calmness... which does not actually go away after 2 weeks as it does with benzodiazepines, or without the cognitive deficits. |
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1) Dose escalation as tolerance builds. Either through increased dosages or attempting another ROA like rectal to temporarily increase bioavailability.
2) Patients are usually upset if they don't have a dissociative experience.
3) Many patients wish that they could afford IV treatments and to do them much more often.
4) Many patients claim that oral and intranasal ketamine doesn't work for them despite studies showing that it does work well. Obviously oral ketamine won't cause the rather extreme disassociation of IV ketamine.
All the signs are there. And yes you are right about the euphoria. I have experienced it but it's not a topic that often comes up. People are more interested in talking about the woo woo stuff.
The same moderator runs all the ketamine subreddits -- even those where people are addicted and sharing advice on how to get high. Sort of a bias / conflict of interest, right?