[74B5]

Thank you for your optimism, now let me balance that out a little.

Propulsion maybe the easier part of engineering. Afaik we are nowhere near to life support and environment control that could be considered stable for a time period of maybe 10 years or more.

The biggest biological advantage, adaptation is meaningless for large organism on such a timescale and maybe dangerous on a microbial level.

[Udo]

You are correct that we are nowhere near that in life support technology, however, there don't seem to be an fundamental hurdles there. If we end up opting for a biological life support system, adaptation would not even enter the equation - it'd be a matter of genetic engineering. An obvious danger would always be onboard ecosystem collapse, of course.