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by mikevm 1583 days ago
The spike protein in the vaccine is not fully inert: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084611

> The free-floating Spike proteins synthetized by cells targeted by vaccine and destroyed by the immune response circulate in the blood and systematically interact with angiotensin converting enzyme 2 (ACE2) receptors expressed by a variety of cells including platelets, thereby promoting ACE2 internalization and degradation. These reactions may ultimately lead to platelet aggregation, thrombosis and inflammation mediated by several mechanisms including platelet ACE2 receptors. Whereas Phase III vaccine trials generally excluded participants with previous immunization, vaccination of huge populations in the real life will inevitably include individuals with preexisting immunity. This might lead to excessively enhanced inflammatory and thrombotic reactions in occasional subjects. Further research is urgently needed in this area.
2 comments
echelon 1583 days ago
In the case of vaccine only / no infection, is vaccine-mediated inflammation long lasting and damaging? These effects in the paper (platelet aggregation, thrombosis) seem to be capable of causing permanent harm. Platelet aggregation seems like it would cause small amounts of systemic endothelial damage, atherosclerosis, thombrosis, ...

The level of inflammation no doubt varies on a case by case / individual basis, but is it possible that nobody gets out of the pandemic without some level of stress on their pulmonary and circulatory systems?

To state this succinctly, did Covid (whether infected or vaccinated) shave a few days off of all of our lives?

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rsfern 1583 days ago
That paper was interesting and the bit about clinical trials is important, but they don’t really offer much evidence that there are substantial concentrations of free floating spike proteins in the blood following vaccination, or that this would be the cause of the inflammatory and thrombotic reactions, vs just the more general immune response

As far as I can tell they’re just citing this one paper about the ACE2 degradation, and the study doesn’t directly address SARS-CoV-2 infection or vaccination at all.

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4231883/?r...

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