[dumdumdumdum]

> "We hypothesize that evolution is influenced by two sources of information: External information that is natural selection, and internal information that is accumulated in the genome through the generations and impacts the origination of mutations,"

But how was that internal information accumulated? Through natural selection? Couldn't people in Africa have a higher rate of generating the HbS mutation de novo, because other parts of their parents genome encodes that information? Like when a zygote is getting spliced up you're more likely to get errors where HbS gene is in Africa because they've inherited another gene that causes those errors because of natural selection.

I don't understand the distinction they're making between "natural selection" and "internal information that is accumulated in the genome through the generations". To me that sounds the same. But perhaps I've been thinking about natural selection all wrong.