[tripletao]

All claims I've seen that Malone is "the" inventor of mRNA vaccine technology trace back to Malone himself. He possibly has some real claim to be "an" inventor, among the top dozen or so contributors of early advances that ultimately enabled the present vaccines. It's also possible that the contribution he's claiming as his own was basically his supervisor's idea (Felgner's), and Malone is just the one who did the lab work:

https://www.nature.com/articles/d41586-021-02483-w

Either way, I'm pretty sure Malone's claims about vaccine safety are dangerously wrong. After literally billions of doses of mRNA vaccines, the adverse effects he's been warning about simply haven't materialized. The rate of those effects isn't zero, and surveillance at mass scale has identified adverse effects that the original trials weren't powered to detect; but for now, the risk/benefit ratio for the vaccines looks highly favorable. Malone's baseless assertions otherwise are causing real harm.

That said, please don't take anything above as a defense of Fauci or of censorship. While I'm pretty sure that Malone is dangerously wrong, this pandemic has repeatedly demonstrated that the mainstream consensus can also be dangerously wrong--so like the Royal Society, I'd rather tolerate false information from the contrarians than risk a false mainstream view that can never get corrected. That doesn't mean contrarians are automatically (or even usually) right, though.

"Follow the money" may sometimes be a useful standard, but I don't see the relevance here. Fauci appears to get his money from the government, where he's the single highest-paid employee but still earns less than countless anonymous tech workers. This seems more to me like a matter of prestige, ego and power for both men.

[berdario]

> I'd rather tolerate false information from the contrarians than risk a false mainstream view that can never get corrected. That doesn't mean contrarians are automatically (or even usually) right, though

I don't. I think it's reckless to tolerate contrarian information (and in fact, it's causing a much higher death toll during this pandemic) in public.

I agree that specialists should still be allowed to discuss contrarian information, via papers, peer review and the overall scientific process.

But should Software Engineers (like most of us here) really be warranted a platform, a listening audience on their ideas about virology?

[imbnwa]

What exactly is the "false mainstream view that can never get corrected"? I'm likely out of the loop to some extent, but WRT, e.g masks, that was retracted and corrected; vaccines prevent transmission/reception, that was retracted and corrected. What else am I missing, or is it simply that people don't like "flip-flopping", which is strange cause there wasn't massive outrage at the way "cigarettes don't give you cancer" was propagated, or Absestos, etc

[tripletao]

In the two examples that you give, I don't think there was significant censorship of the initially-contrarian viewpoints ("masks are likely enough to protect against SARS-CoV-2 that they're worth a try", "the vaccine is highly effective against death and serious illness but much less so against infection long-term"). Perhaps in part because of that open discussion, those viewpoints indeed quickly became the mainstream.

I was thinking more of stuff like the origin of the pandemic. It's far from proven, but I believe it's entirely possible that (a) the SARS-CoV-2 pandemic originated from reckless virological research; (b) if this research continues, then new pandemics will occur by similar means in future, with similar or worse mortality; and (c) the only force likely to prevent that is public outcry against continued funding of such research. For about a year, discussion of this possibility was grounds for a ban from Facebook. It's only thanks to the huge reputational risks taken by a small number of researchers that this topic has now entered the mainstream. Without those few dozen people, we could easily have landed in a world where that topic remained forbidden indefinitely.

Closer to the Malone case, the BMJ published an article alleging improper conduct by a contractor that conducted some of Pfizer's vaccine trials. (For emphasis, they're not saying that any of these allegations, even if true, would mean the vaccine is unsafe. The point is to expose and correct localized procedural failures before they become patient safety failures.) Facebook marked this as "partly false information", and indicated that users who shared the article would see their posts deprioritized. This has been widely publicized, and Facebook hasn't changed its position.

https://www.bmj.com/content/bmj/376/bmj.o95.full.pdf

So if the vaccine were actually dangerous, then would I ever find out? (Again, I strongly believe the vaccine is safe; but I'm asking this hypothetically.) I think I still would for now, because the censorship on the major platforms isn't complete, and I spend enough time on other platforms that they don't have total control anyways. It's not a comforting trend, though.

[berdario]

We know how the pandemic originated, let's stop spreading FUD and propaganda

https://www.microbe.tv/twiv/twiv-762/

[tripletao]

A group of authors including Ralph Baric, the father of modern coronavirology, published a letter in Science calling for investigation of all possible origins of the pandemic, explicitly including a research accident:

https://www.science.org/doi/10.1126/science.abj0016

Last I checked, Baric still thought a natural origin was more likely; but the point is that he considers an unnatural origin sufficiently likely that an open investigation is required. The FBI assessed with "moderate" confidence that the pandemic had unnatural origin, while some other agencies assessed with "low" confidence that it was natural and the rest declined to judge.

We don't know how the pandemic originated. Nothing is proven in either direction, but mainstream consensus now absolutely includes the possibility that it originated from such a research accident. Your dismissal of that as "FUD and propaganda" now puts you in a position as fringe as the opposite would have been eighteen months ago. From your other comment, I guess you think I should have been censored for entertaining it back then. But given that the mainstream consensus has since changed--apparently without you realizing--do you believe that you should be censored for rejecting it now?

Unless you somehow become our dictator, you are unlikely to find that the censors' arbiter of truth always agrees with you. Specifically on this website, I believe that Paul Graham is our dictator; and from his Twitter account, I'm pretty sure he disagrees with you on this matter:

https://twitter.com/paulg/status/1396769717805780994

https://twitter.com/paulg/status/1396787092726984707

He surely can afford to moderate as strictly as he wants. But he doesn't seem too inclined to censorship, so you got to post your comment. I'm fine with that, among other reasons because it gave me the chance to explain the basis for my beliefs, and possibly change your mind (or that of someone else reading).

As to your link, I assume you're aware that the host and guests on TWiV have advocated for and performed exactly the kind of high-risk research that may have caused this pandemic? That certainly gives them special expertise that deserves attention, but to trust only them on this question is like trusting only Monsanto on herbicide safety.

[berdario]

These are some fair points, but I have some objections:

> mainstream consensus now absolutely includes the possibility...

I don't think this is the case... Your belief is obviously different to Ralph Baric's which is yet different to the belief of those who worked in the Wuhan laboratory.

I.e. the scientific consensus was that it was extremely unlikely, Baric now says that this is less likely than the zoonotic origin, and you say "entirely possible".

You can use the catch-all "includes the possibility" to treat all of them together, but if you had to pick numbers for the probability of the lab leak, you'd likely pick different numbers than Baric or others.

I.e. just because something is not impossible but merely "extremely unlikely" it's still reckless to have our media talk about it in the way it has.

If anything, if the real consensus is that we don't know... The media should not carelessly talk about any hypothesis without also mentioning the others, and why they are more/less likely.

This is not a topic that needs to he hashed and rehashed every few weeks: the consequence of treating this like it has been done, is that now a bunch of people think that the lab peak is what actually happened, and just today I've seen another article which defends Joe Rogan by saying that there's "consensus on the lab leak hypothesis"...

I.e. if there should be censoring about this, both me and you should be censored, for not being concrete and impartial enough.

> I'm pretty sure he disagrees with you on this matter

I'm not sure what this appeal to authority wants to imply. Of course the decision process for how/when to censor it's a delicate one, and ideally left far away from millionaires who think that they are more competent than they actually are.

To clarify, just because a private person owns a platform, it doesn't mean that they should be the only ones to make rules on what contents are allowed. They can make things stricter, but they shouldn't be able to make things laxer by allowing what's otherwise illegal (obviously, that depends on jurisdiction, which is why countries censor websites via DNS or routing)

> I assume you're aware that the host and guests on TWiV have advocated for and performed exactly the kind of high-risk research

The only people who describe this as "high-risk" are also the people who believe in a lab leak being actually what happened

Do you think that EVERY "gain of function" experiment is high risk?

[tripletao]

> If anything, if the real consensus is that we don't know... The media should not carelessly talk about any hypothesis without also mentioning the others, and why they are more/less likely.

As I said in my previous comment in exactly those words, "We don't know how the pandemic originated". So I'd certainly agree that the media should make that clear. (I mean that as my personal opinion, not a call for censors to force them to.)

Given that we don't know, regardless of whether one thinks a research accident caused the pandemic with p = 0.01 or p = 0.99, I believe that an investigation of all possible causes is required. Ralph Baric and I probably disagree on the exact probabilities, but we agree on the investigation. There are many significant unexplored paths for that, even without the PRC's cooperation, including subpoenas for the records of the WIV's American collaborators.

With millions dead, such an investigation is inevitably political. You'd probably rather the investigation were left to scientific experts, and I would too; but someone has to choose those experts. In a democracy, that job goes to elected politicians. The performance of those politicians is ultimately judged by the voters. Without open discussion, I don't see how the voters could make an informed choice. (I guess the politicians could decide what information the voters deserve to know, and the voters could judge the politicians according to that filtered information; but I assume you see the flaw in that system.)

> I'm not sure what this appeal to authority wants to imply. Of course the decision process for how/when to censor it's a delicate one, and ideally left far away from millionaires who think that they are more competent than they actually are.

I mentioned Paul Graham's beliefs not because they were specially valuable in themselves, but because under present American law, he's probably the person with authority to decide what is censored on this site. If he were inclined to censor, then I don't think he'd decide in your favor.

It seems like you believe American law should be changed, by amending the constitution to eliminate the First Amendment, and the American government should exercise strong powers of censorship over such forums directly. That seems very unlikely to happen. But even if it did, a majority of Americans (including a majority of Democrats) believe not only that an unnatural origin of COVID is possible, but that it's the most likely explanation:

https://www.newsweek.com/most-republicans-democrats-believe-...

So if the American government were censoring, then do you really think they'd be censoring in your favor? If you think stronger government censorship early in the pandemic might have changed public opinion now, then remember that Trump was president at that time. If his government had had that power, then I can't imagine you'd have been pleased with how they used it.

It seems like you're hoping for censorship in the abstract, in service of perfect truth. That can't exist. Censors are humans, and censorship is subject to the same mistakes and corruption as any other human endeavor, especially those affecting the flow of political power. All of this requires human judgment; and once the wrong humans get the job, any apparatus designed to suppress falsehood works just as well to suppress truth.

> Do you think that EVERY "gain of function" experiment is high risk?

Almost any biological experiment involving genetic engineering (or even just culture with artificial selective pressure) may be reasonably anticipated to cause some gain of function. Most such experiments present minimal risk.

The research of concern is the search for deadlier and faster-spreading human potential pandemic pathogens, whether by laboratory gain of function or by collection from nature in areas with minimal other human traffic and thus minimal risk of natural spillover. This was a concern even before this pandemic, and is absolutely a concern even to those who believe that's not the origin of this pandemic:

> “That’s screwed up,” the Columbia University virologist Ian Lipkin, who coauthored the seminal paper arguing that covid must have had a natural origin, told the journalist Donald McNeil Jr. “It shouldn’t have happened. People should not be looking at bat viruses in BSL-2 labs. My view has changed.”

https://www.technologyreview.com/2021/06/29/1027290/gain-of-...